A mechanical bond tied directly onto a protein, in water.
Rotaxanes are made in organic solvent by chemists who like organic solvent. Making them in water, on a peptide or a protein, was the moment my chemistry stopped being only chemistry.
Done during a Miller Fellowship at Berkeley with Matthew Francis. It is why almost everything since has had biology in it.
Carson J. Bruns, Associate Professor, ATLAS Institute and the Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder.
Carson J. Bruns